Tottenham boss Jose Mourinho already has an injury headache to deal with from the international break after Sergio Reguilon hobbling off the pitch in Spain’s 0-0 draw with Portugal on Wednesday.
Some national teams face three fixtures this international break with domestic managers undoubtedly concerned about how their players will be when they return.
Tottenham have 12 first-team players out on international duty and the fixtures got underway on Wednesday.
Summer signing Pierre-Emile Hojbjerg didn’t play any part in Denmark’s opening game against Faroe Islands.
Similarly, Hugo Lloris was rested for France as they thrashed Ukraine 7-1.
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But Reguilon was in action for Spain as they faced Cristiano Ronaldo’s Portugal side.
And Mourinho’s worst fears were realised as he was brought off at half-time due to an injury problem.
The full-back could be seen hobbling off the pitch and Spain boss Luis Enrique offered a worrying update after the game.
“It is a blow that the doctors have to see,” he said.
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“I hope it doesn’t get complicated.”
Mourinho will undoubtedly be hoping to hear good news from Spain’s medical team once an assessment is done.
Reguilon has made an impressive start to life at Tottenham, helping them to big wins over Manchester United and Chelsea.
Spurs are next in action against West Ham on October 18 before starting their Europa League group stage against LASK just four days later.
Mourinho will have eyes on a number of international fixtures tonight as well with a handful of players expected to feature.
Toby Alderweireld and Serge Aurier could come up against each other with Belgium taking on Ivory Coast.
England trio Eric Dier, Harry Kane and Harry Winks are also likely to be involved in the game against Ben Davies’ Wales.
Spurs right-back Matt Doherty is also in action for the Republic of Ireland in their Euro 2020 qualifying play-off against Slovakia.
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