Liverpool captain Jordan Henderson is expected to miss around three weeks with a hamstring injury, meaning Jurgen Klopp will have to reshuffle his midfield for the clash with West Ham.
Henderson was withdrawn in the 80th minute of last Tuesday's 1-0 Champions League defeat to Atletico Madrid.
And manager Klopp recently revealed that the Reds skipper is likely to be out for action for at least three weeks.
It means Naby Keita is set to replace the England star for Monday night's Premier League tussle with struggling West Ham.
Klopp doesn't have any other new injury concerns, though, and it expected to field his strongest XI as the Reds continue to close in on the league title crown.
Liverpool can re-establish their 22-point advantage at the top of the Premier League with a win over the Hammers.
But Georginio Wijnaldum recently claimed the players do not got ahead of themselves.
"Think of one game at a time, try to give everything every game and at the end you will see what will happen," he said. "We don't really think about results and those things.
"We just think about the game and try to give everything we have and do as good as possible so we have the biggest chance to win the game.
"Until now, it went quite well, really well, so we hope we can continue this run until the end."
Monday's clash is less than a month since Liverpool won 2-0 away to West Ham in the reverse fixture.
Wijnaldum admitted Liverpool had found West Ham a tough nut to crack as they defended in numbers.
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