Arsenal boss Mikel Arteta is set to make seven changes from the team that battled to a 3-2 victory over Everton on Sunday for the visit of Olympiacos.
Alexandre Lacazette scored a late away goal in Athens to give the Gunners the advantage going into the second leg at the Emirates.
And although Arteta is set to rotate his options, a number of high profile players are set to return to the starting lineup.
The Spaniard is able to field a strong side without fear of fatigue, as Arsenal's Premier League match with Manchester City has been postponed from this weekend due to the latter playing Aston Villa in the League Cup final.
As such, first leg goalscorer Lacazette is set to start up front, flanked by the dangerous duo of Gabriel Martinelli and Pierre-Emerick Aubameyang.
18-year-old Martinelli has exploded onto the scene this season and has scored three goals in the Europa League, while Aubameyang was at the double to see off Everton at the weekend.
Elsewhere, a youthful central midfield trio sees Joe Willock operate in front of Lucas Torreira and Matteo Guendouzi, with the latter set to feature after putting a training ground spat with Arteta behind him.
Arsenal's centre-half pairing of Shkrodan Mustafi and David Luiz is set to continue, but there are due to be changes at full-back.
Bukayo Saka is set to play at left-back after Sead Kolasinac went off with a shoulder injury described as "significant" by Arteta.
The 18-year-old produced a wonderful assist for Eddie Nketiah at the weekend and could prove a handful down the left flank.
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