Big 12 odds, lines, point spreads: Updated Week 1 betting information for every game

The Big 12 must look to avoid the upset bug in Week 1 of the college football season. 

That didn’t happen in 2020. Iowa State, Kansas State and Kansas were all victims of upsets by Sun Belt schools to start last season, and No. 23 Louisiana will look to do it again on the road at No. 21 Texas on Saturday. 

The Longhorns are 8.5-point favorites against the Ragin’ Cajuns in coach Steve Sarkisian’s debut. Will that line hold up? 

No. 2 Oklahoma also opens the season with national championship hopes, and the road opener against Tulane was moved to Norman because of Hurricane Ida. That boosted the line from 26.5 to 31.5. 

The Big 12 also has two interesting matchups against Power 5 opponents. Kansas State hosts Stanford, and West Virginia travels to Maryland. The other matchups are in the state of Texas, where Baylor welcomes Texas State and Texas Tech travels to Houston. 

Four Big 12 teams open with FCS schools. Kansas opens with South Dakota on Friday in Lance Leipold’s debut. Oklahoma State hosts Missouri State, Iowa State opens with Northern Iowa and TCU plays Duquesne on Saturday. That leaves six Big 12 games on the schedule. 

For more college football predictions, check out Sporting News’ Week 1 picks against the spread: 


Before Oklahoma leaves for the SEC, they have another Big 12 championship to win — unless Iowa State can stop them. #football #college #sooners #big12

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