The undercard for Anthony Joshua's box-office clash with Oleksandr Usyk wil feature the return of Callum Smith and cruiserweight world champion Lawrence Okolie.
Joshua will defend his unified world titles against Usyk who steps up to the blue-ribbon division for the third time since becoming undisputed cruiserweight champion.
Smith has been out of action since his unanimous decision defeat to pound-for-pound king Canelo Alvarez, and will now step up to light-heavyweight against Lenin Castillo on September 25.
Recently-crowned cruiserweight champion Okolie also makes his ring return following a crushing stoppage victory over Krzystof Glowacki, when he takes on undefeated Dilan Prasovic in a mandatory defence.
Sky Sports' Adam Smith has previewed the night of action labelling it "exciting" ahead of a Matchroom Boxing show's return to the popular outlet in the UK after Eddie Hearn secured a broadcasting switch to DAZN.
"Joshua vs. Usyk will be an unmissable evening of action, with Lawrence Okolie, Callum Smith and Campbell Hatton all featuring on a bumper bill at Tottenham Hotspur Stadium, live on Sky Sports Box Office," Smith said.
"We've followed Lawrence Okolie's career since the start and he'll be determined to light up north London with an explosive defence of his WBO Cruiserweight belt.
"Callum Smith is on a collision course with new World Title rivals, having joined the Light-Heavyweight division, and Campbell Hatton continues his journey up the pro ranks with the help of Matthew and Ricky Hatton.
"AJ and Usyk then take centre stage as two Olympic gold medallists collide in the capital, in a hugely important World Heavyweight Title clash!"
At the top of the bill, Joshua was previously set to face domestic rival Tyson Fury this year in an undisputed clash, but he has been forced into taking his WBO mandatory defence after the 'Gypsy King' was forced to withdraw from the planned contest and take on Deontay Wilder in a trilogy bout.
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And the British heavyweight has revealed that he is "looking to trim" and come into the contest lighter in a "fight for the brain" against the tricky Ukrainian.
"I'm looking trim for this fight. I'm fighting a guy who is a 12-round fighter. So it would be silly of me to go in there bulky with my muscles screaming for oxygen," he told Sky Sports.
"I've been training like a 15-round fighter in this camp. I will be well-conditioned to fight. That is key. What happens when I train that way? My body adapts and takes its natural form. This is the form it has taken.
"Also I practice having the ability to [punch] four times, not just once. It's a fight for the brain. Knowing what you've got in front of you and knowing how to deal with it.
"You can either be aggressive, corner [him], throw everything at it. Or take your time, be clever, then knock [him] out."
Later on the card, young star Campbell Hatton is set to feature as he takes on his fourth professional fight, while powerful welterweight and crowd-pleaser Florian Marku makes his return in a rescheduled bout against Maxim Prodan.
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